Triptolide, also called triptolide in Tripterygium Wilfordii Hook, it has a long history, wide application of traditional Chinese medicine. Triptolide ( Triptolide, TPL ) is one of the main active constituents of Tripterygium wilfordii, has anti-inflammatory and immunosuppressive effects. Molecular formula: C20H24O6, molecular weight: 360.4, insoluble in water, soluble in methanol, two dimethyl sulfoxide, anhydrous ethanol, chloroform, ethyl acetate. In 2012 October, the United States University of Minnesota researchers found, mouse models displaying of triptolide on treatment of pancreatic carcinoma effectively. The researchers then on triptolide processing, finally get a water-soluble, injectable drug prescribed, pheromone, the medicine to kill tumor cells and shrink the tumor effect is excellent, no doubt for patients with pancreatic cancer brings new hope.
Effect of triptolide on extraction separation and purification method:
Medicinal herb Tripterygium wilfordii crushing sieving 100 mesh, methanol / ethanol extraction for 3 times, decompression concentrating evaporation to remove solvent, acetonitrile water phase extraction, concentration, chloroform extraction, concentration, SKS-30-200 alumina chromatography chloroform methanol separation, SKS -10-4300 gel chromatography of triptolide in greater than 98% purity.
Development of the SKP-10-450 can be used for Bonaventure triptolide related derivatives of separation and purification, the purity of the product reached more than 99%.
This process is the Ji'nan Biological Technology Co。 Ltd。 all, for more details please contact us。